Bioreactors and Fermenters for Bioprocessing

Automatic Multistage Continuous Bioreactor

(Stainless Steel Bioreactor System)

The Automatic Multistage Continuous Bioreactor is a bioreactor system that combines scalability with integrated control. Designed specifically to simulate the microbial process scale-up, it can operate multiple fermentation stages (continuous or parallel) simultaneously, ensuring a smooth transition of processes from laboratory development to industrial production.

Key Parameters
  • Capacity:
    1. First-Stage Seed Vessel: 30L / 50L / 100L
    2. Fermentation Vessel: 300L / 500L / 1000L / 2000L
    3. Customizable range: 5L - 1000L, supports multi-stage customization
  • Vessel Material: SUS316L / SUS304 Stainless Steel
  • Surface Finish: Inner surface High-Precision Polish (Ra≤0.4); Outer surface polish (Ra≤0.6)
  • Working Volume: 30% - 75%
  • Temperature: Heating/Cooling dual control; Precision: ±0.2℃
  • pH: 0-12 (±0.01), Bi-directional Auto-Regulation (Acid/Alkali)
  • DO (Dissolved Oxygen): 0-200% (±0.1)
  • Sterilization: Fully Automatic SIP (Steam-In-Place). Includes sterilization timing, pressure holding, and independent filter sterilization
  • Pressure: 0 - 3 bar (Precision 0.01 bar), supports digital setting and automatic regulation
FZ-DS Series Multistage Fermenter (Cost-Effective)

It is a high-cost-performance series that features full automation for temperature and pressure, while flow rate is controlled manually.

Model FZ-DS Series Multistage Fermenter (Cost-Effective)
Control Functions Temperature Measure & Control Seed Vessel:
30L / 50L / 100L
Fermentation Vessel:
300L / 500L / 1000L / 2000L
PH Measure & Control
DO Measure & Control
Agitation Speed Variable Frequency
Sterilization Automatic
Pressure Measure & Control
Flow Rate Manual
Acid/Alkali Auto-Control
Foam Control Auto-Control
Feeding Peristaltic Pump
FZ-ES Series Multistage Fermenter (Advanced)

Features advanced automation capabilities, including full automatic measurement and control of flow rates and pressure, allowing for fully simulating the operation of large-scale industrial vessel operations.

Model FZ-ES Series Multistage Fermenter (Advanced)
Control Functions Temperature Measure & Control Seed Vessel:
30L / 50L / 100L
Fermentation Vessel:
300L / 500L / 1000L / 2000L
PH Measure & Control
DO Measure & Control
Agitation Speed Variable Frequency
Sterilization Automatic
Pressure Measure & Control
Flow Rate Measure & Control
Acid/Alkali Auto-Control
Foam Control Auto-Control
Feeding Peristaltic Pump
Please find below some examples of customized FZ-ES series multi-stage fully automatic fermenter that we have supplied to clients.
FZ-ES-30L-300L (2-Stage Automatic Fermenter)
FZ-ES-30L-300L (2-Stage Automatic Fermenter)
  • Seed Vessel: 30L
  • Fermentation Vessel: 300L
FZ-ES-50L-500L (2-Stage Automatic Fermenter)
FZ-ES-50L-500L (2-Stage Automatic Fermenter)
  • Seed Vessel: 50L
  • Fermentation Vessel: 500L
FZ-ES-100L-2000L (2-Stage Automatic Fermenter)
FZ-ES-100L-2000L (2-Stage Automatic Fermenter)
  • Seed Vessel: 100L
  • Fermentation Vessel: 2000L
FZ-ES-30L-50L-200L (3-Stage Automatic Fermenter)
FZ-ES-30L-50L-200L (3-Stage Automatic Fermenter)
  • Seed Vessel: 30L
  • Fermentation Vessel: 50L, 200L
FZ-ES-10L-50L-500L (3-Stage Automatic Fermenter)
FZ-ES-10L-50L-500L (3-Stage Automatic Fermenter)
  • Seed Vessel: 10L
  • Fermentation Vessel: 50L, 500L
FZ-ES-10L-100L-1000L (3-Stage Automatic Fermenter)
FZ-ES-10L-100L-1000L (3-Stage Automatic Fermenter)
  • Seed Vessel: 10L
  • Fermentation Vessel: 100L, 1000L
FZ-ES-10L-50L-100L-500L (4-Stage Automatic Fermenter)
FZ-ES-10L-50L-100L-500L (4-Stage Automatic Fermenter)
  • Seed Vessel: 10L
  • Fermentation Vessel: 50L, 100L, 500L
FZ-DS-30L-100L-300L (3-Stage Automatic Fermenter)
FZ-DS-30L-100L-300L (3-Stage Automatic Fermenter)
  • Seed Vessel: 30L
  • Fermentation Vessel: 100L, 300L
FZ-DS-10L-100L-1000L (3-Stage Automatic Fermenter)
FZ-DS-10L-100L-1000L (3-Stage Automatic Fermenter)
  • Seed Vessel: 10L
  • Fermentation Vessel: 100L, 1000L
Technical Documentation Download